Assessing the accuracy of direct-coupling analysis for RNA contact prediction

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FIGURE 4.
FIGURE 4.

Geometric-average MCC as a function of threshold scores S for Boltzmann learning and pseudolikelihood DCA. MSAs are performed with ClustalW and Infernal, as indicated. The sharp decrease after some method-dependent value of S is due to the fact that when the threshold is too large the number of correctly predicted contacts in at least one of the 17 investigated systems drops to zero.

This Article

  1. Published in Advance February 27, 2020, doi: 10.1261/rna.074179.119 RNA 26: 637-647

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