FIGURE 3.
The HTLV-1 frameshift site structure is a pseudoknot. (A) The data-driven secondary structure of the HTLV-1 pro-pol frameshift site is shown. Percentages represent helix-wide confidence values determined with bootstrapping methods. Normalized and averaged NMIA nucleotide (NT) reactivities are overlaid onto the structure. Numbering is consistent with the NCBI reference sequence NC_001436.1 and Figure 1B. (B) Normalized and averaged A and C NT reactivities (derived from experiments with DMS) are overlaid onto the structure in A.
