Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human

Ppp1r1b-lncRNA Inhibits EZH2 Binding at the MyoD1 promoter region. C2C12 myoblasts were cultured in growth and differentiation medium (DM) treated with scramble GapmeR and Ppp1r1b-lncRNA GapmeR. Treated C2C12 cells were subjected to ChIP analysis using anti-EZH2 antibodies. The qPCR data are presented as fold enrichment to the background, indicating the EZH2 abundance at the MyoD1 promoter region. (*) P < 0.05; (**) P < 0.01.