Ppp1r1b-lncRNA inhibits PRC2 at myogenic regulatory genes to promote cardiac and skeletal muscle development in mouse and human

Ppp1r1b-ncRNA regulates expression of myogenic regulatory factors and sarcomere structural genes. Real-time PCR analysis of myogenic regulatory factors and sarcomeric structural genes after Ppp1r1b-lncRNA silencing in Mouse C2C12 myoblasts (A), mouse heart tissue (B), human skeletal myoplasts (C), and human-induced pluripotent stem cell-derived cardiomyocytes (hiPSCs-CM) (D). N = 4 biological replicates per condition. Error bars, standard error of the mean. (*) P < 0.05; (**) P < 0.01.