A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

Cases that require nonpreferred ADAR for efficient RNA editing. (A–C) Editing ratios of five sites in the serotonin 5-HT_2CR (A), CACNA1D isoleucine/methionine (I/M) (B), and FLNB glutamine/arginine (Q/R) (C) sites in the indicated tissues isolated from wild-type (WT), Adar1^E861A/E861AIfih^−/− mice (Adar1 knock-in [KI]), and Adar2^−/−Gria2^R/R (Adar2 knockout [KO]) mice are shown. Editing ratios are displayed as the mean ± SEM (n = 3 mice for each group; Student's t-test, [*] P < 0.05, [**] P < 0.01, [***] P < 0.001, n.s., not significant). The editing ratio of each mouse is also displayed as a circle on the right side of each column.