A comparative analysis of ADAR mutant mice reveals site-specific regulation of RNA editing

Sites with up-regulation of editing in either Adar1 KI or Adar2 KO mice. (A–D) Editing ratios for the +4 position of miR-381-3p (A), the +6 position of miR-376b-3p (B), the +3 position of miR-99b-3p (C), and the +4 position of miR-376a-2-5p (D) in indicated tissues isolated from wild-type (WT), Adar1^E861A/E861AIfih^−/− mice (Adar1 knock-in [KI]), and Adar2^−/−Gria2^R/R (Adar2 knockout [KO]) mice are shown. Editing ratios are displayed as the mean ± SEM (n = 3 mice for each group; Student's t-test, [*] P < 0.05, [**] P < 0.01, [***] P < 0.001). The editing ratio of each mouse is also displayed as a circle on the right side of each column.