Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs

Alternative splicing events in five ribosomal protein mRNAs are induced by hypoxia in HEK293 cells. A heat map representing the percent splicing index (PSI; long variant/[short + long variants] × 100) for 68 alternative splicing events (ASEs) in HEK293. Five ASEs (boxed) had a ΔPSI (|hypoxic PSI − normoxic PSI|) ≥ 10%. Nineteen ASEs had a ΔPSI < 10%, 40 had a ΔPSI = 0%, and the ΔPSI was unable to be calculated for three ASEs due to lack of detection or undefined short/long variant. See Supplemental Material source data file for Figure 3.