The origin of the high stability of 3′-terminal uridine tetrads: contributions of hydrogen bonding, stacking interactions, and steric factors evaluated using modified oligonucleotide analogs

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FIGURE 2.
FIGURE 2.

The chemical modifications of the 3′-terminal uridine residue (G-quadruplexes M0–M7). The purple spheres indicate the sites at which groups of atoms were added, removed, or substituted depending on the modification. The figure depicts each modified G-quadruplex in an idealized conformation with a well-formed “reversed” U-tetrad, which many among them do not assume in reality (see text).

This Article

  1. Published in Advance September 23, 2020, doi: 10.1261/rna.076539.120 RNA 26: 2000-2016

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