The shift from early to late types of ribosomes in zebrafish development involves changes at a subset of rRNA 2′-O-Me sites

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FIGURE 3.
FIGURE 3.

Structural comparison of zebrafish early- and late-rRNA with human rRNA. The scaling compared to Supplemental Figures S3–S5 is indicated. (A) Helix 25 in LSU and expansion segment 25ES7a–h showing the deletion of 25ESf, “g,” and “h” and shortening of 25ESa, “b,” “d,” and “e.” (B) Helixes 75-79 and the two expansion segments 78ES30 and 79ES31 in Domain V in LSU with deletion and reduction of 78ES30 in early- and late-LSU, respectively, and elongation of 79ES31b in early LSU. (C) Part of the 5′ domain in SSU focusing on helix 9es3-ac. Segments of high (black) and low (red) degree of conservation, helix numbering (blue), conserved (M; black), and novel zebrafish 2′-O-Me sites (M; blue) are indicated.

This Article

  1. RNA 26: 1919-1934