Site-specific and substrate-specific control of accurate mRNA editing by a helicase complex in trypanosomes

Total RNA editing in RESC6-IPs upon RNAi of REH2C proteins: (A) KH2F1–RNAi, and (B) KREH2–RNAi. Plots of cumulative total editing in RPS12, as in Figure 2B. The same positions as in Figure 2B showed evident changes in cumulative total editing, including T-str position 51 (ES54; empty arrowhead in A and B). Uninduced (−Tet) and induced (+Tet) at days 3 or 4. Values and error bars reflect mean of n = 2 +SD independent biological replicates. Some error bars are tiny. Sliding window analyses are included comparing −Tet to +Tet day 4 (top tier) or +Tet day 3 (bottom tier).