A rare bacterial RNA motif is implicated in the regulation of the purF gene whose encoded enzyme synthesizes phosphoribosylamine

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FIGURE 2.
FIGURE 2.

Consensus sequence and structural model for Fibro-purF motif RNAs and its gene association. (A) Updated consensus model for Fibro-purF motif RNAs based on 30 unique representatives. The putative ribosome binding site (RBS) and start codon for the adjacent purF open reading frame (ORF) is depicted. (B) De novo purine biosynthesis pathway. The Fibro-purF motif is found exclusively upstream of the purF gene (red), which codes for the enzyme amidophosphoribosyltransferase. (PRPP) phosphoribosylpyrophosphate, (PRA) 5-phosphoribosylamine, (AIR) 5-aminoimidazole ribotide, (AICAR) 5-Aminoimidazole-4-carboxamide ribonucleotide. (C) The chemical structures of PRA and its corresponding carbocyclic analog C-PRA.

This Article

  1. Published in Advance August 25, 2020, doi: 10.1261/rna.077313.120 RNA 26: 1838-1846

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