Processing of Alu small RNAs by DICER/ADAR1 complexes and their RNAi targets

Predicted binding sites of Alu siRNAs in the 3′UTR of CDCP1 mRNAs. One putative target site of Alu siRNA-S2 or -S3 is located in the antisense AluJb located in the CDCP1 3′UTR. Two potential binding sites of Alu siRNA-S1 or -S4 are located in the CDCP1 3′UTR. Black box: seed sequence. The AluJb in the CDCP1 3′UTR located at chr3:45083628–45083942. S2 and S3 Alu siRNAs most likely originated from their target site regions of the corresponding sense Alu strand. Similarly, S1 and S4 Alu siRNAs likely originated from their first (upstream) target site regions of the corresponding sense Alu strand.