Conserved protein and RNA domains of the telomerase catalytic core. (A) The conserved domain architecture of the telomerase reverse transcriptase (TERT) catalytic protein subunit, including the telomerase essential amino-terminal (TEN) domain, the RNA-binding domain (TRBD), the reverse transcriptase (RT) domain, and the carboxy-terminal extension (CTE). (B) The conserved domain organization of the human telomerase RNA (TR), including the template/pseudoknot (t/PK) domain, the stem terminal element (STE), and the H/ACA box motif. (C) Conserved regions 4 and 5 (CR4/5) domain of the human TR (hTR) comprised of stems P5, P6, and P6.1. Nucleotide numbering system used throughout the study is indicated together with the corresponding nucleotide numbering within full-length hTR in parentheses.
