The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

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FIGURE 3.
FIGURE 3.

Structural diversity of the xrRNALT fold. (A) Sequence differences at J1/2 lead to the formation of the G8–C27 pair with L2B in PLRV (left; color coding as in Fig. 1C). Similar view for SCNMV (right). (B) In vitro Xrn1 degradation assay of PLRV xrRNALT WT and G8–C27 mutants. (C) Architecture of the L2ACN and L2APK regions in PLRV (left) and SCNMV (right). (D) In vitro Xrn1 degradation assay of PLRV xrRNA WT and L2ACN mutants.

This Article

  1. Published in Advance August 26, 2020, doi: 10.1261/rna.076224.120 RNA 26: 1767-1776

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