Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing

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FIGURE 4.
FIGURE 4.

Differential pri-miRNA processing between NL and HCC. (A) Heat-map of pri-miRNA levels of the 24 differentially processed pri-miRNAs between HCC and NL. miRNAs are shown with the most statistically significant changes between NL and HC at the top (miR122) and increasing P-values toward the bottom (miR106b). (B) Increased processing efficiency of pri-miRNAs in HCC compared to NL for miR-122 and miR-21. Shown is the processing efficiency as determined by RNA sequencing in all 40 HCC or all nine NL samples. (****) P < 0.0001, Wilcoxon rank test.

This Article

  1. Published in Advance July 15, 2020, doi: 10.1261/rna.076240.120 RNA 26: 1726-1730

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