PDCD4 regulates translation of several neurite growth-related genes evidenced by Ribo-seq and RNA-seq. The putative PDCD4 targets are present in previously described axonal transcriptomes. (A) Expression of neurite and axon growth-related genes is represented by a heatmap, where an induced expression at translation level is detected in the absence of PDCD4. (B) Venn diagram showing the intersection between the potential PDCD4 targets and axonal transcriptomes derived from mESc (Zappulo et al. 2017; Nijssen et al. 2018). Separate and overlapping expressions between samples are shown. Only transcripts with a level of expression of TPM ≥ 1 were considered. The table shows the type of neuron used in each study, the total genes detected and the number of common genes between potential PDCD4 targets (or potential PDCD4 targets related to axonal growth) and each axonal transcriptome. The EASE Score (a modified Fisher exact P-value) is also shown, which indicates gene enrichment.
