Cover image

Methylphosphate capping enzyme methyltransferase domain in complex with 5′ end of 7SK RNA (PDB id: 6dcc; Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J. 2019. Structural basis of 7SK RNA 5′-γ-phosphate methylation and retention by MePCE. Nat Chem Biol 15: 132–140). 7SK recognition is achieved by protein contacts to a 5′-hairpin-single-stranded RNA region. RNA is displayed as a red ribbon; block bases use NDB colors: A—red, C—yellow, G—green, U—cyan; enzyme is displayed as a gold ribbon; enzyme cofactor inositol hexakisphosphate is shown as spheres. The image was generated using 3DNA/blocview and PyMol software. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu).