Pdc2/Pat1 increases the range of decay factors and RNA bound by the Lsm1–7 complex

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FIGURE 6.
FIGURE 6.

Model for how Pat1 increases specificity and assembly for different mRNA decay factors. (A) Proposed thermodynamic coupling between Pat1 (blue), Lsm1–7 (red), and RNA binding to promote multimerization of the Pat1/Lsm1–7 complex. (B) Binding of oligomeric Pat1 assemblies to multivalent Dcp1/Dcp2 (purple) complexes promotes phase separation and recruitment of additional mRNA decay factors.

This Article

  1. Published in Advance June 8, 2020, doi: 10.1261/rna.075812.120 RNA 26: 1380-1388

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