MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection

MiR-146a abundance in the CVB3-infected cells. (A,B) Primary cardiac fibroblasts isolated from Balb/c mouse were infected with CVB3 (MOI = 5). Total RNA was collected at 24 and 48 h p.i. and subjected to miRNA array detection. (C–E) HeLa cells were infected with CVB3 (MOI = 1). The abundances of miR-146a, miR-21, and miR-186 at 0, 6, 12, 24, and 36 h p.i. were detected by RT-qPCR with the ΔΔC_T method. The abundance of miRNAs was normalized by U6 (miRNAs). Error bars represent standard deviation (SD), n = 4.