Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature

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FIGURE 7.
FIGURE 7.

mRNA expression of PRPF40B and its paralog PRPF40A in various human cancers by RNA-seq (TCGA). (A) In AML, PRPF40A is highly expressed at higher levels than solid tumors, while PRPF40B expression is lower. (B) Inverse correlation between PRPF40B and HIF1A mRNA levels in AML (t-test). (C) Positive correlation between PRPF40A and HIF1A mRNA levels in AML (t-test).

This Article

  1. Published in Advance May 14, 2019, doi: 10.1261/rna.069534.118 RNA 25: 905-920

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