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Crystal structure of the metY SAM V riboswitch (Protein Data Bank code: 6fz0; Huang L, Lilley DMJ. Structure and ligand binding of the SAM-V riboswitch. 2018. Nucleic Acids Res 46: 6869–6879). The RNA riboswitch backbone is displayed as a red ribbon; bases are shown as blocks with NDB coloring: A—red, C—yellow, G—green, U—cyan; the intercalating S-adenosylmethionine (SAM) ligand is shown in spacefill with element colors: C—white, N—blue, O—red, S—yellow. The image was generated using 3DNA/blocview and PyMol software. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu).