Roles of specific aminoglycoside–ribosome interactions in the inhibition of translation

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FIGURE 1.
FIGURE 1.

2-DOS aminoglycosides bind h44 and H69 of the ribosome in a similar way. Co-crystal structures with Neo (A) and Gen (B) are shown as examples. Thumbnail on the right shows the perspective of view. 16S rRNA is colored beige, with key A-site nt A1492 and A1492 (violet) and h44 nt A1408 and G1491 (red) highlighted. 23S rRNA is colored gray, with H69 highlighted in light cyan. Aminoglycosides (as indicated) are shown as space-filled models. Images were made using PDB entries 4V52 and 4V53.

This Article

  1. Published in Advance November 9, 2018, doi: 10.1261/rna.068460.118 RNA 25: 247-254

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