Iron-induced transferrin receptor-1 mRNA destabilization: A response to “Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation”
- 1Department of Health Management, Tokai University, Hiratsuka, Kanagawa, 259-1292 Japan
- 2Minnesota Department of Health, St. Paul, Minnesota 55164, USA
- 3Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi 466-8550, Japan
- 4Department of Biological Sciences, Toxicology Program, North Carolina State University, Raleigh, North Carolina 27695, USA
- Corresponding authors: m.miyazawa{at}tsc.u-tokai.ac.jp, ytsuji{at}ncsu.edu
Abstract
We read with great interest the Divergent Views article by Connell and colleagues disputing our recent publication describing a role for two microRNAs in the iron-mediated regulation of transferrin receptor 1 (TfR1) mRNA stability. Our publication sought to shed light on a long-standing question in the field of cellular iron metabolism, and we welcome commentary and critique. However, there are several critical issues contained in the article by Connell and colleagues that require further consideration. We appreciate the opportunity to reply here.
Footnotes
-
Article is online at http://www.rnajournal.org/cgi/doi/10.1261/rna.073270.119.
This article is distributed exclusively by the RNA Society for the first 12 months after the full-issue publication date (see http://rnajournal.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
