The yeast telomerase module for telomere recruitment requires a specific RNA architecture

SHAPE-reactivity results corroborate the predicted secondary structure model of the stem IVc arm of the different Tlc1 RNAs. SHAPE reactivity profiles of the stem IVc arm in the context of the WT, [WT + 3], and ΔCS2 constructs. The regions in which the nucleotides are located in the predicted structures are indicated at the top. The relative reactivities higher than 0.4, between 0.4–0.2, and lower than 0.2 are shown in red, orange, and black, respectively.