Eighty routes to a ribonucleotide world; dispersion and stringency in the decisive selection

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FIGURE 5.
FIGURE 5.

Descent of templating. This figure summarizes the route to inherited, proto-genetic characters. (A) Sporadically fed pools getting varying substrates; a minority makes elevated, useful product. (B) Selected synthesis of active AppA*, via the quantitatively favored cross-templated route. (C) Evolution of templated 5′–3′ RNA synthesis may be stimulated by 5′–5′ ribodinucleotides.

This Article

  1. Published in Advance May 21, 2018, doi: 10.1261/rna.066761.118 RNA 24: 1041-1055

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