Fractional progress toward AppA* templating in one cycle of selection (Δftemp) versus pool age. Solid lines indicate strong selection; dashed lines mild selection. Triangles are pools in constant danger; circles are pools in periodic danger. Means of ten simulations on 1000 pools are plotted; bars around points are standard errors (where invisible, errors are within the mean points). Leftward panels in each pair have a scheme at upper right showing a set of schematic substrate arrivals (random downward arrows) on a 10-d time axis (black rightward arrow). Relevant substrates are listed beneath the timeline. Pools labeled “cross” perform cross-templated synthesis; “para” implies para-templated synthesis. (A) Sporadically fed, cross-templated pool, 1 mM substrates. (B) 10 mM substrates. (C) Simultaneously fed, cross-templated pool, 1 mM substrates. (D) 10 mM substrates. (E) Sporadically fed, para-templated pool, 1 mM substrates. (F) 10 mM; GppG input. (G) Sporadically fed, para-templated pool, 10 mM substrates. (H) 100 mM; pG/ImpG input. (I) Simultaneously fed, para-templated pool, 10 mM substrates. (J) 100 mM; pG/ImpG input.
