Dbp2p binding to other RNA types indicates further links to R-loops. (A,B) Dbp2p, Sen1p binding, and rnh1Δrnh201ΔS1-DRIP-Seq on representative mRNA transcripts. Data are presented as in Figure 2A,B. (C) Metagene plot for Dbp2p iCLIP and rnh1Δrnh201ΔS1-DRIP-Seq for mRNA transcripts (n = 5055). Data were generated and are presented as in Figure 2C. Correlation coefficients and associated P-values were calculated as in Figure 2C,D. The inset shows the Dbp2p iCLIP read distribution for all mRNA transcripts in UTRs and ORF. (D) Dbp2p binding and rnh1Δrnh201ΔS1-DRIP-Seq density on rRNA transcripts. Data are presented as in Figure 2A,B. Mature rRNA transcripts are shown below the sequencing traces. Modification sites are marked according to Piekna-Przybylska et al. (2008). (E) Dbp2p, Sen1p binding, and R-loops on U6 snRNA. Data are presented as in Figure 2A,B. (F) Dbp2p, Sen1p binding, and R-loops on U4 snRNA. Data are presented as in Figure 2A,B.
