Accelerated RNA secondary structure design using preselected sequences for helices and loops

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FIGURE 1.
FIGURE 1.

Trends in natural sequences. Distributions of folding free energy change, ensemble folding free energy change, ensemble defect, and structure probability for 7 bp helices. Cumulative distribution plots are provided in red for unique sequences observed in the database of RNA structures and in blue for all possible helices. Panel A is Gibbs free energy change, panel B is ensemble Gibbs free energy change, panel C is ensemble defect, and panel D is the probability of helix formation.

This Article

  1. Published in Advance August 10, 2018, doi: 10.1261/rna.066324.118 RNA 24: 1555-1567

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