Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme

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FIGURE 7.
FIGURE 7.

Self-cleavage rate constants for wild-type (solid symbols) and N-MCC-6 modified (open symbols) leadzyme sequences. For the wild-type sequence, biexponential decay was observed due to incomplete folding, and the faster of the two resulting rate constants is plotted (cf. Materials and Methods). Relative errors (σn−1) were averaged across a given data set.

This Article

  1. Published in Advance August 15, 2018, doi: 10.1261/rna.067579.118 RNA 24: 1542-1554

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