Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme

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FIGURE 4.
FIGURE 4.

Illustrative R1ρ transverse relaxation curves at γB1/2π = 3.0 KHz for internal-loop peaks. (A) Cyt-6 C2′ (solid); (B) Cyt-6 C4′ (solid). Open symbols in both panels are the helical residue Cyt-28 C2′ for comparison. Curves were normalized such that extrapolated intensity at t = 0 was unity. Error bars were derived from threefold replicas of a single time point.

This Article

  1. Published in Advance August 15, 2018, doi: 10.1261/rna.067579.118 RNA 24: 1542-1554

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