Coupling between conformational dynamics and catalytic function at the active site of the lead-dependent ribozyme

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FIGURE 2.
FIGURE 2.

(A) Three-dimensional representations of the two primary pseudorotational conformations (sugar puckers) observed for ribose rings in nucleic acids. (B) Structure of the North-methanocarba nucleotide modification, which cannot take up South-like sugar pucker conformations, emphasizing the similar presentation of linkages and functional groups to unmodified C3′-endo nucleotides.

This Article

  1. Published in Advance August 15, 2018, doi: 10.1261/rna.067579.118 RNA 24: 1542-1554

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