Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation

A-to-I editing frequencies increase during torpor. (A) Editing frequencies for intronic sites in FBXW7 and CHD9 determined by Sanger sequencing from cerebrum samples (n = 5) at early torpor (ET) or late torpor (LT). Editing frequencies determined by RNA-seq are also shown for comparison. (B) For all cold-enriched sites the average normalized abundance (counts per million) for reads containing reference (A) or edited (G) nucleotides is shown.