Dynamic temperature-sensitive A-to-I RNA editing in the brain of a heterothermic mammal during hibernation

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FIGURE 5.
FIGURE 5.

Predicted functional consequences of editing. (A) Summary of predicted impacts of cold-enriched editing events as defined by SnpEff using Ensembl annotations. (B) Heatmap depicting RNA editing frequencies for editing sites in CDS regions or predicted to be deleterious by SNPeff analysis (Moderate or High impact). Sites without read coverage are colored gray. Columns are ordered by sample group and rows are ordered by hierarchical clustering. (C) Heatmap depicting cold-enriched sites with significant seasonally altered editing frequencies (FDR < 0.01). Comparisons were made between heterothermic warm samples (Ent and IBA) and homeothermic warm samples (SA and SpD). Rows and columns are clustered by hierarchical clustering.

This Article

  1. RNA 24: 1481-1495