Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner

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FIGURE 7.
FIGURE 7.

A proposed mechanism of Sbp1-specific translation regulation. The two RRM domains of Sbp1 bind to 5′UTRs cooperatively, and the center RGG domain recruits proteins such as initiation factor Pab1. These interactions remodel the 5′UTR assembly, leading to changes in the recruitment of the 43S PIC to the target mRNAs and the downstream translational events.

This Article

  1. Published in Advance October 6, 2017, doi: 10.1261/rna.062547.117 RNA 24: 43-55

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