The C-terminal dsRNA-binding domain of Drosophila Dicer-2 is crucial for efficient and high-fidelity production of siRNA and loading of siRNA to Argonaute2

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 1.
FIGURE 1.

Domain structures of Drosophila Dicer-2. (A) Domain structures of the wild-type and truncated mutant Drosophila Dicer-2 used in this study. (B) Anti-HA Western blot detecting the transgenic HA-Dicer-2 proteins in whole transgenic flies.

This Article

  1. Published in Advance April 17, 2017, doi: 10.1261/rna.059915.116 RNA 23: 1139-1153

Current Issue

  1. August 2026, 32 (8)
  1. Current Issue
  1. Alert me to new issues of RNA