FIGURE 4.
A schematic model for the role of Rrp6 as a structural adapter protein. (A) Rrp6 associates with the NURS complex through its interaction with Mtl1. NURS complex associates with Mmi1 bound to early meiosis RNAs during mitosis. Therefore, exosome recruitment to these RNAs is possible and these RNAs are degraded largely by Dis3. Rrp6 degrades only some of the Mmi1 target RNA (depicted by dotted line). (B) Rrp6 facilitates the degradation of iron homeostasis mRNAs during high-iron conditions. It does so presumably by interacting with as yet unidentified RNA-binding proteins that bind to these mRNAs.
