G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme

Model of the TERRA RNA–LSD1 binding interface. Cross-linking mass spectrometry data support a model whereby LSD1 residues (red) in the SWIRM domain interact with a stacked GQ RNA. In addition, X-ray crystallography data identifies an ssRNA binding location (pink), which resides adjacent to the GQ RNA binding site. Binding locations are consistent with a GQ RNA that binds LSD1 in a noncompetitive manner.