Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy

Differential gene expression in Smn hypomorphic animals. (A) Heatmap comparison of Cuffdiff FPKM levels of differentially expressed transcripts. Heatmap colors were rescaled for each row and the rows were clustered based on pattern of gene expression between Smn^WT rescue line and the Smn missense mutants. (B) Venn diagram of overlapping differences in mRNA levels. (C) A heatmap of FPKMs from a set of stress-responsive transcripts. Genotypes are labeled by Smn^Tg, which was expressed in the Smn^X7 null background.