A systematic computational analysis of the rRNA–3′ UTR sequence complementarity suggests a regulatory mechanism influencing post-termination events in metazoan translation

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FIGURE 4.
FIGURE 4.

Evolutionarily conserved regions of statistically significant sequence complementarity between 18S rRNA and 3′ UTRs (ECRCs) cluster around the mRNA entry pore on the 40S ribosomal subunit. ECRCs were projected on the 3D structures of small ribosomal subunits of D. melanogaster (A) and H. sapiens (B). ECRCs are color-coded as follows: ECRC i in red, ECRC ii in green, and ECRC iv in cyan. ECRC iii is not visible in this solvent-exposed subunit projection but can be seen in Figure S2. Ribosomal proteins are colored in white.

This Article

  1. Published in Advance May 17, 2016, doi: 10.1261/rna.056119.116 RNA 22: 957-967

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