A DEAD-box RNA helicase promotes thermodynamic equilibration of kinetically trapped RNA structures in vivo

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FIGURE 9.
FIGURE 9.

Free energy model of secondary structure exchange through RNA chaperone-assisted branch migration. RNA chaperone proteins, like Mss116p, that unwind 1–2 bp per ATP cycle could catalyze the exchange between adjacent RNA helices through small steps with low energy barriers to facilitate assembly of RNA structures with the lowest free energy. Diagram adapted from Mahen et al. (2010).

This Article

  1. Published in Advance January 12, 2016, doi: 10.1261/rna.055178.115 RNA 22: 416-427

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