Cross-backbone templating; ribodinucleotides made on poly(C)

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FIGURE 4.
FIGURE 4.

Initial rates of GppG synthesis, at different ratios of substrate nucleotides, with and without poly(C). Triangles indicate data, poly(C) added; circles denote data without polymer. Dashed lines are calculated, matching the overall velocity and assuming rate ∝ [2MeImpG]*[pG] (curves marked 1:1). Dotted lines are calculated, matching overall velocity and assuming rate ∝ [2MeImpG]2*[pG] (curve marked 2:1), or rate ∝ [2MeImpG]*[pG]2 (curve marked 1:2).

This Article

  1. Published in Advance January 12, 2016, doi: 10.1261/rna.054866.115 RNA 22: 397-407

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