Structural and functional insights into the fly microRNA biogenesis factor Loquacious

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FIGURE 7.
FIGURE 7.

Model for Loqs dimerization and dmDcr1 binding. In the absence of dmDcr1, Loqs forms homodimers via the dimerization interface located on dsRBD3 (green). DsRBD1 and 2 are indicated as orange circles. In the presence of dmDcr1, Loqs binds to the helicase domain of dmDcr1 via the dimerization interface of dsRBD3 and a high-affinity binding site located in the linker preceding dsRBD3 (highlighted in red).

This Article

  1. Published in Advance January 14, 2016, doi: 10.1261/rna.055426.115 RNA 22: 383-396

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