Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

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FIGURE 6.
FIGURE 6.

Model of SF3B1 function in the spliceosome cycle. Spliceosomes assemble on a pre-mRNA substrate through a series of intermediate splicing complexes (E → A → B → C → P). We propose that SF3B1 inhibitors affect assembly at multiple steps by interfering with a conformational change in SF3B1.

This Article

  1. Published in Advance January 7, 2016, doi: 10.1261/rna.053108.115 RNA 22: 350-359

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