Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages

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FIGURE 3.
FIGURE 3.

Branch point region and polypyrimidine tract (PYT) strength do not correlate with compound sensitivity. In vitro splicing efficiencies of pre-mRNA substrates with different branch point regions normalized to DMSO control reactions are shown plotted against (A) SSA (1) or (B) PB (2) concentration. The branch point A is underlined. (C) Same as A using pre-mRNA substrates with different PYT length.

This Article

  1. Published in Advance January 7, 2016, doi: 10.1261/rna.053108.115 RNA 22: 350-359

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