FIGURE 2.
TtCsm6 is a helical homodimer containing N-terminal CARF and C-terminal HEPN domains. (A) Overall architecture of the TtCsm6 dimer shown in four orientations. (B) Comparison of the three-dimensional structures of COG1517 family proteins: P. furiosus Csx1 (PfCsx1, PDB ID 4EOG), S. mutans Csm6 (SmCsm6, PDB ID 4RGP), and S. solfataricus Csa3 (SsCsa3, PDB ID 2WTE). Structural superpositions were performed using DALI (Hasegawa and Holm 2009). (C) Surface representation of the TtCsm6 dimer colored according to electrostatic surface potential. The molecule is displayed in the same orientations as in A.
