An integrative transcriptomics approach identifies miR-503 as a candidate master regulator of the estrogen response in MCF-7 breast cancer cells

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FIGURE 1.
FIGURE 1.

Experimental design. MCF-7 cells were cultured in stripped media for 72 h, then 10 nM E2 was added to the media. RNA was harvested at 0, 1, 2, 3, 4, 5, 6, 8, 12, and 24 h post E2, and paired small RNA and mRNA-seq libraries were generated. Each data set was subject to differential expression analysis, and interactions were predicted between miRNAs and target mRNAs.

This Article

  1. Published in Advance August 18, 2016, doi: 10.1261/rna.056895.116 RNA 22: 1592-1603

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