Genome-wide detection of high abundance N6-methyladenosine sites by microarray

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FIGURE 4.
FIGURE 4.

m6A interferes with A–U or A–T pairing. (A) Pie chart indicating genic location of significant probes (SPs). (B) Bar plots show specific enrichment of SPs on long (>300 nt) versus short (≤300 nt) exons (P < 2.79 × 10−7; Fisher's exact test). (C) Bar plots showing enrichment of the RRACH motif within 206 SPs and remaining probes (P < 6.11 × 10−5; Fisher's exact test). (D) GO analysis of 64 protein-coding genes containing SPs (P < 0.05). The number of gene hits in a GO category is indicated within the bars. (E). Bar plots showing that meRIP-seq peaks containing SPs exhibit significantly decreased binding to AGO2 than do those from remaining probes. Fisher's exact test, P < 0.0012.

This Article

  1. Published in Advance June 19, 2015, doi: 10.1261/rna.051474.115 RNA 21: 1511-1518

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