Profiling ribonucleotide modifications at full-transcriptome level: a step toward MS-based epitranscriptomics

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FIGURE 3.
FIGURE 3.

(A) Anionic MS2 spectrum of methyl-G from S. cerevisiae total RNA digest, which was obtained by activating the m/z 376 species observed in Figure 1; (B) cationic MS3 spectrum obtained by activating m/z 378 → 166 →. The inset displays the MS4 spectrum obtained by activating m/z 378 → 166 → 124 →. Solid arrows indicate possible methylated positions; dashed arrows suggest putative cleavages.

This Article

  1. Published in Advance May 20, 2015, doi: 10.1261/rna.049429.114 RNA 21: 1361-1374

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