Xenopus CAF1 requires NOT1-mediated interaction with 4E-T to repress translation in vivo

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FIGURE 7.
FIGURE 7.

The NOT1 MIF4G domain recruits Xp54 and 4E-T to mediate eIF4E- and cap-independent repression by CAF1. (A) Model of repression when a tethered repressor is on the 3′ end of a reporter mRNA. (B) We propose that repression may occur in a similar manner by RNA-binding proteins that recruit the CAF1/NOT1/Xp54/4E-T complex when bound to target mRNAs.

This Article

  1. Published in Advance May 26, 2015, doi: 10.1261/rna.051565.115 RNA 21: 1335-1345

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