Cleavage cascades of molecules CRZ-2 and PBD1-4. Black numbers correspond to the length of the molecules or to the fragment to be cleaved (5′- and 3′-end). Superscripts 5′, 3′, c, or l mark molecules in a reactive conformation to cleave the 5′-end, the 3′-end, to circularize, or to linearize, respectively. Reversible cleavage reactions are indicated by double arrows, bent arcs denote refolding steps that are considered as irreversible. The line width of arcs is proportional to the refolding rate; red numbers denote the corresponding energy barriers (limiting the refolding rate). The line width of green boxes is proportional to the equilibrium probability of a reactive conformation; green numbers in parentheses denote the corresponding difference between the free energy of the reactive structure and the ensemble free energy.
